Effect of Chlamydiaphage CPG1 on the Course of Conjunctival Infection with “Chlamydia caviae” in Guinea Pigs
نویسندگان
چکیده
Effect of Chlamydiaphage CPG1 on the Course of Conjunctival Infection with “Chlamydia caviae” in Guinea Pigs Roger G. Rank,* Anne K. Bowlin, Stefania Cané, Huizhong Shou, Zhi Liu, Uma M. Nagarajan, and Patrik M. Bavoil Departments of Microbiology and Immunology and Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas, and Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland
منابع مشابه
Effect of Chlamydiaphage phiCPG1 on the course of conjunctival infection with "Chlamydia caviae" in guinea pigs.
Over the last several years, four different phages of chlamydiae, in addition to a phage associated with Chlamydia psittaci isolated from an ornithosis infection in ducks over 25 years ago, have been described and characterized. While these phages and their chlamydial host specificities have been characterized in vitro, there is virtually nothing known about the interaction of the phage with ch...
متن کاملThe effect of infectious dose on humoral and cellular immune responses in Chlamydophila caviae primary ocular infection
Following infection, the balance between protective immunity and immunopathology often depends on the initial infectious load. Several studies have investigated the effect of infectious dose; however, the mechanism by which infectious dose affects disease outcomes and the development of a protective immune response is not known. The aim of this study was to investigate how the infectious dose m...
متن کاملUse of a Guinea Pig-Specific Transcriptome Array for Evaluation of Protective Immunity against Genital Chlamydial Infection following Intranasal Vaccination in Guinea Pigs
Guinea pigs have been used as a second animal model to validate putative anti-chlamydial vaccine candidates tested in mice. However, the lack of guinea pig-specific reagents has limited the utility of this animal model in Chlamydia sp. vaccine studies. Using a novel guinea pig-specific transcriptome array, we determined correlates of protection in guinea pigs vaccinated with Chlamydia caviae (C...
متن کاملOcular pathologic response elicited by Chlamydia organisms and the predictive value of quantitative modeling.
BACKGROUND Chlamydia organisms are a significant cause of ocular and genital tract disease worldwide. Acute inflammatory responses are largely responsible for pathologic changes. METHODS Guinea pigs were inoculated in the conjunctiva with various infectious doses of Chlamydia caviae. We developed a predictive model and thresholds of the ocular pathologic response, on the basis of measurements...
متن کاملPartial protection against chlamydial reproductive tract infection by a recombinant major outer membrane protein/CpG/cholera toxin intranasal vaccine in the guinea pig Chlamydia caviae model.
Chlamydia trachomatis is a major cause of sexually transmitted diseases worldwide. There is currently no vaccine to protect against chlamydial infection of the female reproductive tract. Vaccine development has predominantly utilised the murine model; however, infection of female guinea pigs with Chlamydia caviae more closely resembles chlamydial infection of the human female reproductive tract...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009